The Duke Free Electron Laser Laboratory operates a storage ring based free electron laser light source. This ultraviolet FEL installed on a 1.2 GeV storage ring provides tunable coherent radiation from 400 nm to 193 nm. Intense gamma rays are produced by internal backscattering. Active areas of research at DFELL include FEL physics, nuclear physics, materials science, and biological and biomedical sciences.

The Duke FEL Laboratory is housed in a 52,000 square foot facility with the addition of the 13,000 square foot Keck Life Sciences Research Laboratory on the campus of Duke University in the Raleigh-Durham-Chapel Hill area of North Carolina.